Profile
Shengrong Guo
Professor
Shengrong Guo
Professor
Dr Shengrong Guo
Professor in Pharmaceutics, School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China. Email: srguo@sjtu.edu.cn; Tel: (86)-21-3420-4793; Fax: (86)-21-3420-4793
1.EDUCATION
1992-1995 Ph.D. in Polymer Chemistry and Physics Zhejiang University, China
1987-1990 M.Sc. in Physical Chemistry Zhejiang University, China
1983-1987 B.Sc. in Chemistry Hubei Normal University, China
2.EMPLOYMENT HISTORY
Jan 2003- Professor
Shanghai Jiao Tong University (2004，as visiting scholar at Georgia Institute of Technology )
2000-2002 Associate Professor
Shanghai Jiao Tong University
1999-2000 Associate Professor
Fudan University (Former Shanghai Medical University)
1996-1999 Lecturer
Fudan University (Former Shanghai Medical University)
3.AWARDS AND HONORS:
Pharmaceutical Science Award (2011, Chinese Pharmaceutical Association)
Pharmaceutical Science Award (2008, Pharmaceutical Association of Shanghai)
Outstanding Life Science Award (2007, Mingzhi Ruye Life Science Awards, Administration Committee)
4.PROFESSIONAL ACTIVITIES:
1)Reviewer for Funding/Awarding Agencies: National Natural Science Foundation of China; Doctoral Program Foundation, Ministry of Education, China; Outstanding Young Awards of Zhejiang Province in China; Natural National Science Foundation of Shanghai in China; Phosphor Awards of Shanghai; Nanoscale Science and Engineering, Basic Science Research, Key Scientific Research of Shanghai
2)Reviewer for international journals: J. Control. Release; Int. J. Pharm.; Biomat.; J. Pharm. Sci.; J. Biomed. Nanotech.; FEBS J.; Poly. Degrad. Stab.; J. Biomat. Sci.; Poly.; Eur. Poly. J.; and J. Appl. Poly. Sci.
5.RESEARCH GRANTS (2008 ~ 2010, only the SG share amount is given here)
· National 973 Basic Research Program of China “Applied basic research on targeted gene therapy” (2010CB529902, RMB 400K, 2010-2015)
· National Comprehensive Technology Platform for Innovative Drug R&D in China
(2009ZX09301-007, RMB 300K, 2009-2010)
· National Special Platform for New Drug R&D in China “Technology Platform for Biotech Drug Delivery” (2009ZX09310-007, RMB 300K, 2009-2010)
· National Natural Science Foundation of China “Study on esophageal stent for sustained, unidirectional and site-specific Drug Release” (30872554, RMB 310K, 2009-2011, PI)
· National Science and Technology Support Plan Program of China “Study on comprehensive prevention and treatment of echinococcosis” (2006BAI06B06, RMB 405K, 2008-2010)
· Specialized Research Foundation for the Doctoral Program of Higher Education in China “Preparation and application of tumor-targeting bioabsorbable micellar nanocarrier” (22090073110087, RMB 60K, 2010-2012, PI)
· National Natural Science Foundation of China “Folate-targeting nanoscale non-viral gene delivery system for osteoarthritis treatment”(30901882, RMB 105K, 2009-2011)
· Key Science and Technology Project of Shanghai Science and Technology Committee “R & D of gastrointestinal stents for preventing restenosis”(10441902000, RMB 800K, 2010-2013, PI)
· Key Basic Research Project of Shanghai Science and Technology Committee “Preparation, microstructure and drug controlled release of polyester based polymers” (08JC1411500, RMB 300K, 2008-2010, PI)
· Key Research Project of Shanghai Education Committee “Preparation and application of polyesters as drug carrier” (09ZZ24, RMB 150K, 2009-2011, PI)
· Key Basic Research Project of Shanghai Science and Technology Committee “Chitosan coating on implant for prevention of infection” (08JC1414200, RMB 105K, 2008-2010)
6.Research Results
A) PUBLISHED BOOKS (8 books in total, only 4 are listed here)
B1. “Pharmaceutical Polymers” (in Chinese), chief-editor, People’s Health Press (China), September 2009
B2. “Biodegradable Polymers for Medical and Pharmaceutical Applications” (in Chinese), chief-editor, Chemical Industry Press (China), January 2004.
B3. “Molecular Targeting Cancer Therapy” (in Chinese), Chapter 14 “Anti-tumor Drug Loaded Nanoparticles for Cancer Therapy”, SG as editor, People’s Health Press (China), May 2009.
B4. Textbook of ‘Biopharmacy and Pharmacokinetics’ (in Chinese), SG as one of the editors, People’s Health Press (China) 2011.
B) ISSUED PATENTS (with 10 more patents being filed)
P1. Guo S.-R., Lei L., Wang L.-Y., Wu W.-P., Hong W. “A type of drug-releasing stent with internal supporting backbone”. China invention patent, ZL 2009 1 0052143.6.
P2. Guo S.-R., Lei L., Hong W. “A winged polymeric stent.” China invention patent, ZL 2009 1 0052142.1.
P3. Guo S.-R., Guo Q.-H., Liu J., Wang Z.-M., “an anti-tumor drug particles-loaded stent”. China invention patent, ZL2500 1 0111800.1.
P4. Guo S.-R., Guo Q.-H., “A preparation method for drug-loaded micro-/nanosphere digestive tract stent” China invention patent, 200510030444.0.
P5. Guo S.-R., Cheng L., Liu L., Tang X.-M., “Preparation method for a in situ chitosan hydrogel formulation”. China Invention patent, ZL2008 1 0041212.9.
C) INVITED REVIEWs (* shows SG led publications; IF: Journal Impact factor 2010)
R1* Lei Lei, Shengrong Guo*, Weiluan Chen, Fei Lu, “Stents as a platform for drug delivery”. Expert Opinion on Drug Delivery, 2011, 8(6): 813-831 IF 4.482
R2* Tang, Mu-Fei; Lei, Lei; Guo, Sheng-Rong*; Huang, Wen-Lin, “Recent Progress in Nanotechnology for Cancer Therapeutics.” Chinese Journal of Cancer, 2010, 29: 61-66.
D) REFERRED JOURNAL PAPERS (> 80 in total, only selected papers since 2006 are listed)
J41* Fei Lu, Lei Lei, Yuanyuan Shen, JIngwen Hou, Weiluan Chen, Yanggong Li, Shengrong Guo.* “Effects of amphiphilic PCL-b-PEG-b-PCL copolymer addition on 5-fluorouracil release from biodegradeble PCL films for stent application.” Int. J. Pharm. 2011, DOI:10.1016 / j ijpharm.IF 3.607
J40* Xiaofen Xu, Ling Wang, Shengrong Guo*, Lei Lei and Tingting Tang. “Surface Chemical Study on the Covalent Attachment of Hydroxypropyltrimethyl Ammonium Chloride Chitosan to Titanium Surfaces.”Appl. Surf. Sci., 2011IF 1.793
J39* Jingwen Hou, Changyan li, Liang Cheng, Shengrong Guo*, Tingting Tang. “Study on hydrophilic 5-Flurouracil release from hydrophobic polycaprolactone cylindrical implants”. Drug Dev. Ind. Pharm.IF 1.396
J38* Lei, Lei; Liu, Xi; Shen, Yuan-Yuan; Liu, Jie-Ying; Tang, Mu-Fei; Wang, Zhong-Min; Guo, Sheng- Rong*; “Cheng, Liang Zero-order release of 5-fluorouracil from PCL-based films featuring trilayered structures for stent application”. Eur. J. Pharm. Biopharm. 2011, 78: 49-57 IF 4.304
J37* Zhaoxiang Peng, Bing Tu, Yang Shen, Lin Du, Ling Wang, Shengrong Guo*, Tingting Tang. Quaternized Chitosan Inhibits IcaA Transcription and Biofilm Formation by Staphylococcus on a Titanium Surface. Antimicrob Agents Ch., 2011, 55: 860-866. IF 4.672
J36* Li Liu, Ximin Tang, Yuanyuan Wang, Shengrong Guo* Smart gelation of chitosan solution in the presence of NaHCO3 for injectable drug delivery system. Int. J. Pharm., 2011, 414: 6-15. IF 3.607
J35*Ling Wang, Xiaofen Xu, Shengrong Guo*, Tingting Tang. Novel water soluble phosphonium chitosan derivatives: Synthesis, characterization and cytotoxicity studies.Int. J. Biol. Macromol., 2011, 48: 375-380. IF2.502
J34*Xi Liu, Lei Lei, Jing-Wen Hou, Mu-Fei Tang, Sheng-Rong Guo*, Zhong-Min Wang, Ke-Min Chen Evaluation of two polymeric blends (EVA/PLA and EVA/PEG) as coating film materials for paclitaxel-eluting stent application. J. Mater. Sci.-Mater. M, 2011, 22(2): 327-337. IF 2.325
J33*Yanting Zhang, Jingwen Hou, Changyun Qian, Lei Song, Shengrong Guo* Taxol-loaded Nanoparticles with Methoxy Poly (ethyleneglycol)-b-Poly(ε-caprolactone) as a Novel Additive in the Outer Aqueous Phase. J. Appl. Polym. Sci. 2011, 121(4):2386-2393 IF 1.240
J32*Lei Lei, Shengrong Guo*, Weiluan Chen, Fei Lu. Stents as a platform for drug delivery. Expert Opinion on Drug Delivery. 2011, 8(6): 813-831 IF 4.482
J31*Lei Lei, Xi Liu, Shengrong Guo*, Mufei Tang, Liang Cheng, Ling Tian. 5-Fluorouracil-loaded multilayered films for drug controlled releasing stent application: Drug release, microstructure, and ex vivo permeation behaviors. J. Control. Release, 2010, 146(1): 45-53. IF 7.164
J30*Liang Cheng, Lei Lei, Shengrong Guo* In vitro and in vivo evaluation of praziquantel loaded implants based on PEG/PCL blends. Int J Pharmaceut, 2010, 387 (1-2): 129-138. IF 3.607
J29* Mufei Tang, Jingwen Hou, Lei Lei, Xi Liu, Shengrong Guo*, Zhongmin Wang*, Kemin Chen. Preparation, characterization and properties of partially hydrolyzed ethylene vinyl acetate copolymer films for controlled drug release. Int. J. Pharm., 2010, 400(1-2): 66-73. IF 3.607
J28*Changyan Li, Liang Cheng, Yaqiong Zhang, Shengrong Guo*, Weiping Wu. Effects of implant diameter, drug loading and end-capping on praziquantel release from PCL implants. Int. J. Pharm., 2010, 386(1-2): 23-29. IF 3.607
J27*Peng ZX, Wang L, Du L, Guo SR*, Wang XQ, Tang TT. Adjustment of the antibacterial activity and biocompatibility of hydroxypropyltrimethyl ammonium chloride chitosan by varying the degree of substitution of quaternary ammonium. Carbohydrate Polymers, 2010, 81(2): 275-283. IF3.463
J26*Li Liu, Aibin Shi, Yue’e Fang, Shengrong Guo*, Song Chen, Jin Li. Preparation of chitosan-g- polylactide graft copolymers via self-catalysis of phthaloylchitosan and their complexation with DNA. Reactive & functional polymers, 2010, 70 (5): 301-305. IF 2.546
J25*Guo SR, Wang ZM, Zhang YQ, Lei L, Shi JM, Chen KM, Yu Z . In Vivo Evaluation of 5- Fluoro- uracil-Containing Self-Expandable Nitinol Stent in Rabbits: Efficiency in Long-Term Local Drug Delivery. J. Pharm. Sci., 2010, 99(7): 3009-3018.IF 3.031
J24*Yuanyuan Wang, Li Liu, Shengrong Guo* Characterization of biodegradable and cytocompatible nano-hydroxyapatite/polycaprolactone porous scaffolds in degradation in vitro. Poly. Degrad. Stab., 2010, 95(2): 207-213. IF 2.594
J23*Yanting Zhang, Yaqiong Zhang, Shengrong Guo*, Wenlin Wang. Tyrosine kinase inhibitor loaded PCL microspheres prepared by S/O/W technique using ethanol as pretreatment agent. Int. J. Pharm., 2009, 369(1-2): 19-23. IF 3.607
J22*Li Liu, Xian Xu, Shengrong Guo*, Wei Han. Synthesis and self-assembly of chitosan-based copolymer with a pair of hydrophobic/hydrophilic grafts of polycaprolactone and poly(ethylene glycol). Carbohydrate Polymers, 2009, 75(3): 401-407. IF3.463
J21*Jiong Liu, Shengrong Guo*, Zonghai Li, Li Liu, Jianren Gu, “Synthesis and characterization of stearyl protamine and investigation of their complexes with DNA for gene delivery.” Coll. Surf. B: 2009, 73 (1): 36-41. IF 2.780
J20*Liang Cheng, Shengrong Guo*, Weiping Wu, “Characterization and in vitro release of praziquantel from poly(epsilon-caprolactone) implants.” Int. J. Pharm., 2009, 377: 112-119. IF 3.607
J19*Shaobing Wang, Shengrong Guo,* “Formation mechanism and release behavior of poly (epsilon- caprolactone) microspheres containing disodium norcantharidate”. Eur. J. Pharm. Biopharm., 2008, 69(3): 1176-1181. IF 4.304
J18* Shaobing Wang, Shengrong Guo*, Liang Cheng, “Disodium norcantharidate loaded poly(epsilon- caprolactone) microspheres I. Preparation and evaluation.” Int. J. Pharm., 2008, 350(1-2): 130-137.IF 3.607
J17*ShaobingWang,ShengrongGuo,*Disodium norcantharidate-loaded poly(epsilon-caprolactone) microspheres II. Modification of morphology and release behavior.” Int. J. Pharm., 2008, 353(1-2): 15-20.IF 3.607
J16*Li Liu, Shengrong Guo*, Jiang Chang, Congqin Ning, Changming Dong, Deyue Yan, “Surface modification of polycaprolactone membrane via layer-by-layer deposition for promoting blood compatibility.”J. Biomed. Mater. Res. B, 2008, 87B(1): 244-250. IF 2.220
J15*Chunhua Shen, Shengrong Guo*, Chengfei Lu, “Degradation Behavior of Methoxy Poly(ethylene glycol)-b-Poly(ε-caprolactone) Nanoparticles in Aqueous Solution”. Polym. Adv. Technol., 2008, 19: 66-72. IF 1.776
J14*ShengrongGuo*, Yaqiong Zhang, “Morphology of poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) assemblies in diluted aqueous solution and gel studied by atomic force microscopy.” Polym. Adv. Technol., 2008, 19(11): 1451-1454.IF 1.532
J13*Shengrong Guo*, Yaqiong Zhang.Concentration controlled multilevel self-assembly of 3-armed poly(ethylene glycol)-b-poly(epsilon-caprolactone) block copolymers investigated by AFM. J. Polym. Sci. Pol. Phys., 2008, 46(13): 1412-1418. IF 1.298
J12* Qinghai Guo, Shengrong Guo*, Zhongmin Wang. “A type of esophageal stent coating composed of one 5-fluorouracil-containing EVA layer and one drug-free protective layer: In vitro release, permeation and mechanical properties.” J. Control. Release, 2007, 118(3): 318-324.IF 7.164
J11* Yaqiong Zhang, Shengrong Guo*, Chengfei Lu, Li Liu, Zonghai Li, Jianren Gu, “Poly(epsilon- caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) triblock copolymers: Synthesis and self-assembly in aqueous solutions.” J. Polym. Sci. Pol. Chem., 2007, 45(4): 605-613.IF 3.894
J10* Qinghai Guo, Shengrong Guo,* “Estimation of 5-fluorouracil-loaded ethylene-vinyl acetate stent coating based on percolation thresholds.” Int. J. Pharm., 2007, 333(1-2): 95-102.IF 3.607
J9* Yiye Lu, Li Liu, Shengrong Guo,* “Novel amphiphilic ternary polysaccharide derivates chitosan- g-PCL-b-MPEG: Synthesis, characterization, and aggregation in aqueous solution.”Biopolymers, 2007, 86(5-6): 403-408.IF 2.572
J8* Chunhua Shen, Shengrong Guo*, Chengfei Lu, “Degradation Behavior of Star-Shaped Poly(ethylene glycol)-Poly(ε-caprolactone) Nanoparticles in Aqueous Solution.” Polym. Degrad. Stab., 2007, 92: 1891-1898 IF 2.594
J7 Bizhi Shi, Huamao Wang, Shengrong Guo, Yuhong Xu, Zonghai Li, Jianren Gu, “Protein III-based single-chain antibody phage display using bacterial cells bearing an additional genome of a gene-III-lacking helper phage.”BioTechniques, 2007, 42(6): 760-765. IF 2.550
J6* Chengfei Lu, Li Liu, Shengrong Guo*, Yaqiong Zhang, Zonghai Li, Jianren Gu, “Micellization and gelation of aqueous solutions of star-shaped PEG-PCL block copolymers consisting of branched 4-arm poly(ethylene glycol) and polycaprolactone blocks,” Eur. Polym. J., 2007, 43 (5): 1857-1865. IF 2.517
J5* Na Zhang, Shengrong Guo,* “Synthesis and micellization of amphiphilic poly(sebacic anhydride)- poly(ethylene glycol)-poly(sebacic anhydride) block copolymers.” J. Polym. Sci. Pol. Chem., 2006, 44(3): 1271-1278. IF 3.894
J4* Li Liu, Fangzhi Li, Yue’e Fang, Shengrong Guo, “Regioselective grafting of poly(ethylene glycol) onto chitosan and the properties of the resulting copolymers”. Macromol. Biosci., 2006, 6(10): 855-861.IF 3.458
J3* Na Zhang, Shengrong Guo*, Huiqin Li, Li Liu, Zonghai Li, Jianren Gu, “Synthesis of three types of amphiphilic poly(ethylene glycol)-block-poly (sebacic anhydride) copolymers and studies of their micellar solutions.” Macromol. Chem. Phys., 2006, 207(15): 1359-1367. IF 2.437
J2* Chengfei Lu, Shengrong Guo*, Yaqiong Zhang, “Synthesis and aggregation behavior of four types of different shaped PCL-PEG block copolymers.” Polym. Int., 2006, 55(6): 694-700. IF 2.056
J1* Chengfei Lu, Shengrong Guo*, Li Liu, Yaqiong Zhang, Zonghai Li, Jianren Gu, “Aggregation behavior of MPEG-PCL diblock copolymers in aqueous solutions and morphologies of the aggregates.” J. Polym. Sci. Pol. Phys., 2006, 44(23): 3406-3417. IF 1.298
